Programme at a glance

Programme at a glance, Virtual

CEST (Central European summer time)

Thursday, 26 August 2021
01.00 - 23.59
WCO-IOF-ESCEO
14.00 - 17.50
Channel 1
SCIENTIFIC SESSION I
Chairpersons: Cyrus Cooper, Nicholas Harvey
14.00
Channel 1
ROS-IOF-ESCEO Symposium
‣ Royal Osteoporosis Society’s Osteoporosis and Bone Research Academy – Our journey towards a cure
Chairpersons: Cyrus Cooper, Neil Gittoes
Royal Osteoporosis Society Research Roadmap: the patient perspective
An introduction to the Royal Osteoporosis Society’s Osteoporosis and Bone Research Academy Juliet Compston
The Research Road Map: Our journey towards a cure Nicholas Harvey
Exploring the research priorities : Causes and mechanisms Stuart Ralston
Exploring the research priorities : Optimising effectiveness of assessments and treatment Eugene McCloskey
Exploring the research priorities : Novel technologies for skeletal assessment Emma Clark
Q&A session
15.30
Channel 1
Opening of the Congress
Cyrus Cooper
15.40
Channel 1
Plenary Lecture 1
Management of musculoskeletal disease from cradle to grave Cyrus Cooper
16.10
Channel 1
Guest lecture
Feast or Famine: How Nutrient Intake Regulates Bone Remodeling Cliff Rosen
16.40
Channel 1
Presentation of prizes and awards
Presentation of the IOF Olof Johnell Science Award, the IOF President’s Award and the ESCEO-IOF Herbert Fleisch Medal Cyrus Cooper
Presentation of the IOF Medal of Achievement Nicholas Harvey
17.50 - 19.30
Channel 1
SCIENTIFIC SESSION II
Chairpersons: John A. Kanis, René Rizzoli
17.50
Channel 1
Plenary Lecture 2
Building bone strength with anabolic agents Michael R. McClung
18.20
Channel 1
Best clinical papers published in 2020
René Rizzoli
19.00
Channel 1
Meet-The-Expert Session
Transgender medicine, bone and muscle Jean‑Marc Kaufman
19.30
Channel 1
Adjournement
Friday, 27 August 2021
01.00 - 23.59
WCO-IOF-ESCEO
09.00 - 11.50
Channel 1
SCIENTIFIC SESSION III
Chairpersons: Jean‑Yves Reginster, Manju Chandran
09.00
Channel 1
Plenary Lecture 3
Management of bone disease in cancer Robert E. Coleman
09.30
Channel 1
Plenary Lecture 4
Thyroid, bone and cartilage Graham Williams
10.00
Channel 1
Meet-The-Expert Session
Impact of glucocorticoids on bone and muscle Evelien Gielen
10.30
Channel 1
Oral communication selected from abstracts
‣ OC1 - RECENT SENTINEL FRACTURES AND SUBSEQUENT FRACTURE PROBABILITIES OVER TWO, FIVE AND 10-YEAR TIMEFRAMES
Presenting author: H. Johansson
Authors: E. V. McCloskey, N. C. Harvey, V. Gudnason, G. Sigurdsson, K. Siggeirsdottir, M. Lorentzon, E. Liu, L. Vandenput, W. D. Leslie, J. A. Kanis
10.40
Channel 1
Meet-The-Expert Session
HIV and bone Emmanuel Biver
11.10
Channel 1
Oral communication selected from abstracts
‣ OC2 - ASSOCIATIONS BETWEEN BONE AND VASCULAR HEALTH IN THE UK BIOBANK
Presenting author: Z. Raisi‑Estabragh
Authors: L. Biasiolli, J. Cooper, N. Aung, K. Fung, J. Paiva, M. Sanghvi, R. Thomson, E. M.  Curtis, J. Paccou, J. Rayner, K. Werys, H. Puchta, K. Thomas, A. M. Lee, S. Piechnik, S. Neubauer, P. B.  Munroe, C. Cooper, S. E. Petersen, N. C. Harvey
11.20
Channel 1
Plenary Lecture 5
Bone and cartilage talk together Ali Mobasheri
11.50 - 12.00
Channel 1
BREAK 10'
13.30 - 15.20
Channel 1
SCIENTIFIC SESSION IV
Chairpersons: Evelien Gielen, Radmila Matijevic
13.30
Channel 1
Plenary Lecture 6
Are there treatments for sarcopenia? Marjolein Visser
14.00
Channel 1
Meet-The-Expert Session
Is screening for osteoporosis useful? E. M. Curtis
14.30
Channel 1
Oral communication selected from abstracts
‣ OC3 - A MULTICENTER, OBSERVATIONAL, EXTENSION STUDY EVALUATING THE SAFETY, TOLERABILITY, AND EFFICACY OF A SINGLE LORECIVIVINT INJECTION IN KNEE OA SUBJECTS
Presenting author: J. Tambiah
Authors: I. Simsek, C. Swearingen, H. Ghandehari, S. Kennedy, N. Skrepnik, Y. Yazici
14.40
Channel 1
Meet-The-Expert Session
Calcium-vitamin D, still a role in osteoporosis management? Elaine M. Dennison
15.10
Channel 1
Oral communication selected from abstracts
‣ OC4 - FRACTURE RISK IN PARKINSON'S DISEASE: DRIVEN BY LOW BONE STRENGTH, MUSCLE WEAKNESS OR FALLS?
Presenting author: P. Bhattia
Authors: E. V. McCloskey, H. Shreef, H. Johansson, M. Lorentzon, N. C. Harvey, J. A. Kanis
15.20 - 15.30
Channel 1
BREAK 10'
15.30 - 16.55
Channel 1
SCIENTIFIC SESSION V
Chairpersons: Claudia Campusano, Maria Luisa Brandi
15.30
Channel 1
Plenary Lecture 7
Gut microbiome, bone and joint Georg Schett
16.00
Channel 1
Meet-The-Expert Session
Rehabilitation after fragility fracture Olivier Bruyère
16.30
Channel 1
Oral communication selected from abstracts
‣ OC5 - PREVALENCE AND AGREEMENT BETWEEN RECENT SARCOPENIA DEFINITIONS: FINDINGS FROM FOUR POPULATION-BASED COHORTS
Presenting author: L. D. Westbury
Authors: H. E. Syddall, J. A. Cauley, P. M. Cawthon, E. M.  Curtis, K. Ensrud, R. A. Fielding, H. Johansson, J. A. Kanis, M. K. Karlsson, T. Kwok, N. Lane, M. Lorentzon, D. Mellström, A. B.  Newman, C. Ohlsson, E. Orwoll, E. Ribom, B. E. Rosengren, J. T. Schousboe, E. J. Shiroma, N. C. Harvey, E. M. Dennison, C. Cooper
16.40
Channel 1
Presentation of prizes and awards
Presentation of the 2020 ESCEO Medal of Excellence, the IOF CNS Medal, the ESCEO-IOF Pierre Meunier Young Scientist Award and the ESCEO-IOF Young Investigator Awards Jean‑Yves Reginster
Presentation of the ESCEO-AgNovos Healthcare Young Investigator Awards Jean‑Yves Reginster, James Howe
16.55 - 17.00
Channel 1
BREAK 05'
18.30
Channel 1
Adjournement
Saturday, 28 August 2021
01.00 - 23.59
WCO-IOF-ESCEO
09.30 - 11.20
Channel 1
SCIENTIFIC SESSION VI
Chairpersons: Charlotte Beaudart, Stefania Maggi
09.30
Channel 1
Plenary Lecture 8
Is genetics helping to improve osteoporosis management ? Emma Duncan
10.00
Channel 1
Meet-The-Expert Session
Fracture during childhood and adolescence Kate Ward
10.30
Channel 1
Oral communication selected from abstracts
‣ OC9 - MAINTENANCE OF EFFECT OF BUROSUMAB TREATMENT AND THE IMPACT OF TREATMENT INTERRUPTION ACROSS A 96-WEEK PHASE 3 STUDY AND 48 WEEKS OF A PHASE 3B STUDY IN ADULTS WITH X-LINKED HYPOPHOSPHATEMIA (XLH)
Presenting author: P. Kamenicky
Authors: K. Briot, M. L. Brandi, M. Cohen‑Solal, R. Crowley, R. Keen, S. Kolta, R. Lachmann, S. Ralston, J. Walsh, A. Rylands, A. Williams, W. Sun, A. Nixon, M. Nixon, K. Javaid
10.40
Channel 1
Meet-The-Expert Session
Discussion of complex bone disorder clinical cases Nicholas R. Fuggle and Roland Chapurlat
11.10
Channel 1
Oral communication selected from abstracts
‣ OC14 - PARATHYROIDECTOMY IS ASSOCIATED WITH REDUCED RISK OF FRACTURE AND CARDIOVASCULAR EVENTS IN PATIENTS DIAGNOSED WITH PRIMARY HYPERPARATHYROIDISM - A NATIONAL, RETROSPECTIVE COHORT STUDY
Presenting author: M. Lorentzon
Authors: K. F. Axelsson, M. Wallander, H. Johansson, N. C. Harvey, L. Vandenput, E. V. McCloskey, L. Enwu, J. A. Kanis, H. Litsne
09.30 - 11.20
Channel 2
SCIENTIFIC SESSION VII
Chairpersons: Friederike Thomasius, Etienne Cavalier
09.30
Channel 2
Oral communication selected from abstracts
‣ OC6 - GLUCOSAMINE SULPHATE: AN UMBRELLA REVIEW OF HEALTH OUTCOMES
Presenting author: N. Veronese
Authors: J. Demurtas, L. Smith, J.‑Y. Reginster, O. Bruyère, G. Honvo, S. Maggi
09.40
Channel 2
Oral communication selected from abstracts
‣ OC7 - THE ASSOCIATIONS BETWEEN DISEASE MODIFYING ANTIRHEUMATIC DRUGS AND INCIDENT AS WELL A PROGRESSION OF RADIOGRAPHIC HAND OSTEOARTHRITIS IN RHEUMATOID ARTHRITIS PATIENTS
Presenting author: T. Burkard
Authors: C. Lechtenboehmer, S. Reichenback, U. A. Walker, A. M. BURDEN, T. Hügle
09.50
Channel 2
Oral communication selected from abstracts
‣ OC8 - MEANINGFUL IMPROVEMENTS IN WOMAC PAIN AND PHYSICAL FUNCTION IN THREE PHASE 3 TRIALS OF TANEZUMAB IN PATIENTS WITH MODERATE-TO-SEVERE OSTEOARTHRITIS: A RESPONDER ANALYSIS
Presenting author: P. Conaghan
Authors: R. H. Dworkin, T. J. Schnitzer, F. Berenbaum, R. Yang, A. G. Bushmakin, J. C. Cappelleri, M. T. Brown, L. Viktrup, L. Abraham
10.00
Channel 2
Meet-The-Expert Session
Lyosis Software - A new way to manage FLS centers more efficiently and cost optimized Werner Fehn
10.30
Channel 2
Oral communication selected from abstracts
‣ OC10 - ROMOSOZUMAB EFFICACY AND SAFETY IN EUROPEAN PATIENTS: A SUBANALYSIS OF THE PHASE 3, RANDOMISED FRAME STUDY
Presenting author: B. Langdahl
Authors: L. C. Hofbauer, S. Ferrari, Z. Wang, A. Fahrleitner‑Pammer, E. Gielen, P. Lakatos, E. Czerwinski, E. Jodar‑Gimeno, J. Timoshanko, M. Oates, C. Libanati
10.40
Channel 2
Oral communication selected from abstracts
‣ OC11 - MULTIDIMENSIONAL PROGNOSTIC INDEX AND THE RISK OF FRACTURES: AN 8-YEAR LONGITUDINAL COHORT STUDY IN THE OSTEOARTHRITIS INITIATIVE
Presenting author: N. Veronese
Authors: L. Smith, E. Zigoura, M. Barbagallo, L. Dominguez, C. Cooper, R. Rizzoli, J.‑Y. Reginster, S. Maggi, A. Pilotto
10.50
Channel 2
Oral communication selected from abstracts
‣ OC12 - THE PREVALENCE OF COMMUNITY-DWELLING OLDER ADULTS AT HIGH FRACTURE RISK WHO ARE NOT TAKING OSTEOPOROSIS MEDICATIONS: RESULTS FROM THE CANADIAN LONGITUDINAL STUDY ON AGING (CLSA)
Presenting author: C. McArthur
Authors: A. Lee, H. Abu Alrob, J. D. Adachi, L. Giangregorio, L. Griffith, S. N. Morin, L. Thabane, G. Ioannidis, J. Lee, W. D. Leslie, A. Papaioannou
11.00
Channel 2
Oral communication selected from abstracts
‣ OC13 - PATIENT'S PREFERENCES FOR LIFESTYLE CHANGES IN OSTEOPOROTIC FRACTURE PREVENTION: A CROSS-EUROPEAN DISCRETE-CHOICE EXPERIMENT
Presenting author: C. Beaudart
Authors: A. Boonen, N. Li, S. Bours, S. Goemaere, J.‑Y. Reginster, C. Roux, B. MCGOWAN, A. Diez‑Perez, R. Rizzoli, C. Cooper, M. Hiligsmann
11.10
Channel 2
Oral communication selected from abstracts
‣ OC15 - FRAILTY IS ASSOCIATED WITH INFLAMMATION AND REDUCED BONE MINERAL DENSITY INDEPENDENT OF FAT MASS: FINDINGS FROM UK BIOBANK
Presenting author: E. M.  Curtis
Authors: S. D'angelo, S. Woolford, R. Durdin, Z. Raisi‑Estabragh, K. A. Ward, C. Cooper, N. C. Harvey
11.20 - 13.20
Channel 1
SCIENTIFIC SESSION VIII
Chairpersons: Gemma Adib, Mickaël Hiligsmann
11.20
Channel 1
Meet-The-Expert Session
Can we influence fracture repair? Julio Fernandes
11.50
Channel 1
Oral communication selected from abstracts
‣ OC18 - LOCAL OSTEO-ENHANCEMENT PROCEDURE SIGNIFICANTLY INCREASES BONE MINERAL DENSITY IN THE PROXIMAL FEMUR OF POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS AT HIGH RISK FOR HIP FRACTURE
Presenting author: De Schepper
Authors: J. Howe, J. Shaul, J. Coteur, B. Huber
12.00
Channel 1
Meet-The-Expert Session
FLS and fracture risk reduction Kassim Javaid
12.30
Channel 1
Oral communication selected from abstracts
‣ OC23 - QUALITY OF LIFE, RESOURCE USE AND COSTS RELATED TO FRAGILITY FRACTURES: DEVELOPMENT AND EVALUATION OF MULTIDISCIPLINARY POST-FRACTURE CARE PATHWAYS
Presenting author: J. Talevski
Authors: K. Sanders, J. Watts, L. Busija, A. Beauchamp, G. Duque, F. Borgström, J. A. Kanis, A. Svedbom, A. Stuart, S. Brennan‑Olsen
12.40
Channel 1
Meet-The-Expert Session
How to warrant reliable data for calciotropic hormones and bone turnover markers assays Etienne Cavalier
13.10
Channel 1
Oral communication selected from abstracts
‣ OC29 - CORTICAL PORE SIZE DISTRIBUTION AND VISCOELASTIC HUMAN TIBIA PROPERTIES DISCRIMINATE FRAGILITY FRACTURES INDEPENDENT OF BONE MINERAL DENSITY
Presenting author: K. Raum
Authors: G. Armbrecht, H. Minh Nguyen, J. Massmann
13.20
BREAK 40'
11.20 - 14.30
Channel 2
SCIENTIFIC SESSION IX
Chairpersons: Helena Johansson, Emmanuel Biver
11.20
Channel 2
Oral communication selected from abstracts
‣ OC16 - EPIGENETIC AGE ACCELERATION ASSOCIATIONS WITH SKELETAL OUTCOMES: DIFFERENTIAL IMPACTS IN MEN AND WOMEN
Presenting author: N. R. Fuggle
Authors: M. A. Clynes, M. O’breasail, C. Parsons, J. W. Holloway, A. Kitaba, K. A. Ward, C. Cooper, E. M. Dennison
11.30
Channel 2
Oral communication selected from abstracts
‣ OC17 - COMPARISON OF FRACTURE RATES AND ECONOMIC OUTCOMES BETWEEN WOMEN WITH OSTEOPOROSIS RECEIVING RISEDRONATE GASTRO-RESISTANT (GR) AND ALENDRONATE
Presenting author: F. Thomasius
Authors: S. Palacios, A. Alam, M. Boolell, F. Vekeman, G. Gauthier
11.40
Channel 2
Oral communication selected from abstracts
‣ OC19 - A PROSPECTIVE OPEN-LABEL OBSERVATIONAL STUDY OF A BUFFERED SOLUBLE 70 MG ALENDRONATE EFFERVESCENT TABLET ON UPPER GASTROINTESTINAL SAFETY AND MEDICATION ERRORS: THE GASTROPASS STUDY
Presenting author: S. Minisola
Authors: A. Ponce Vargas, G. Letizia Mauro, F. Bonet Madurga, G. Adami, D. M. Black, N. Qizilbash, J. Blanch Rubió
11.50
Channel 2
Oral communication selected from abstracts
‣ OC20 - OSTEOCALCIN, MUSCLE FUNCTION AND 15-YEAR FALLS-RELATED HOSPITALISATIONS IN OLDER WOMEN: THE PERTH LONGITUDINAL STUDY OF AGEING WOMEN
Presenting author: C. Smith
Authors: J. R. Lewis, M. Sim, W. H. Lim, E. M. Lim, L. C. Blekkenhorst, T. Brennan‑Speranza, L. Adams, E. Byrnes, G. Duque, I. Levinger, R. Prince
12.00
Channel 2
Oral communication selected from abstracts
‣ OC21 - RELATIONSHIPS BETWEEN MALNUTRITION, SARCOPENIA, AND FRAILTY AND THE INCIDENCE OF COVID-19 IN OLDER ADULTS: DATA FROM THE SARCOPHAGE COHORT
Presenting author: L. Lengelé
Authors: M. Locquet, M. Moutschen, C. Beaudart, J.‑F. Kaux, S. Gillain, C. Shadouh, J.‑Y. Reginster, O. Bruyère
12.10
Channel 2
Oral communication selected from abstracts
‣ OC22 - FUNCTIONAL BRAIN PROCESSES IN SARCOPENIA - EVIDENCE FOR DIFFERENTIAL CENTRAL NEURAL MECHANISMS IN DYNAPENIC OLDER ADULTS
Presenting author: W. Trost
Authors: A. Trombetti, M. Hars, N. Fernandez, F. Herrmann, T. Chevalley, S. Ferrari, G. Gold, R. Rizzoli, P. Vuilleumier
12.20
Channel 2
Oral communication selected from abstracts
‣ OC24 - UC-II® COLLAGEN HELPS SUPPORT KNEE JOINT MOBILITY IN HEALTHY SUBJECTS: A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY
Presenting author: V. Juturu
Authors: K. Knaub, W. Alt, C. Schön, S. Durkee, Z. Saiyed
12.30
Channel 2
Oral communication selected from abstracts
‣ OC25 - 10-YEAR TRENDS IN PREVALENCE OF RADIOGRAPHIC HIP OSTEOARTHRITIS IN JAPANESE MEN AND WOMEN: COMPARISON OF BASELINE AND 4TH RESEARCH ON OSTEOARTHRITIS/OSTEOPOROSIS AGAINST DISABILITY STUDY SURVEYS
Presenting author: T. Iidaka
Authors: S. Muraki, H. Oka, C. Horii, K. Nakamura, T. Akune, S. Tanaka, N. Yoshimura
12.40
Channel 2
Oral communication selected from abstracts
‣ OC26 - SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF AN INTRA-ARTICULAR CORTICOSTEROID INJECTION ADMINISTERED 7 DAYS BEFORE OR AFTER INTRA-ARTICULAR LORECIVIVINT INJECTION INTO THE SAME KNEE OF HEALTHY VOLUNTEERS: AN OPEN-LABEL, PARALLEL-ARM STUDY
Presenting author: Y. Yazici
Authors: A. Halseth, S. Kennedy, C. Swearingen, I. Simsek, M. Fineman, N. E. Lane
12.50
Channel 2
Oral communication selected from abstracts
‣ OC27 - EFFECT OF 2 FORMS OF VITAMIN D ON SKELETAL MUSCLE FIBER SIZE AND VITAMIN D RECEPTOR (VDR) CONCENTRATION IN YOUNGER POSTMENOPAUSAL WOMEN
Presenting author: L. Ceglia
Authors: D. Rivas, M. Schlögl, H. A. Bischoff‑Ferrari, B. Dawson‑Hughes
13.00
Channel 2
Oral communication selected from abstracts
‣ OC28 - NEUROFILAMENT-LIGHT CHAINS (NF-L), A BIOMARKER OF NEURONAL DAMAGE, IS INCREASED IN SARCOPENIC PATIENTS: RESULTS OF THE SARCOPHAGE STUDY
Presenting author: A. Ladang
Authors: S. Kovacs, L. Lengelé, M. Locquet, J.‑Y. Reginster, O. Bruyère, E. Cavalier
14.00 - 17.00
Channel 1
SCIENTIFIC SESSION X
Chairpersons: Elaine M. Dennison, Bess Dawson‑Hughes
14.00
Channel 1
Meet-The-Expert Session
Management of men with osteoporosis Alberto Ferlin
14.30
Channel 1
Oral communication selected from abstracts
‣ OC30 - IN HEALTHY MEN, EARLY DECLINE IN TRABECULAR BONE MINERAL DENSITY IS, IN PART, RELATED TO DECREASES IN SEX STEROIDS
Presenting author: T. Banica
Authors: C. Verroken, H. Zmierczak, S. Goemaere, J.‑M. Kaufman, B. Lapauw
14.40
Channel 1
Plenary Lecture 9
Rehabilitation of menopausal hormone therapy in osteoporosis management Irene Lambrinoudaki
15.10
Channel 1
Oral communication selected from abstracts
‣ OC31 - MULTICENTER PROSPECTIVE STUDY TO ASSESS EFFICACY AND SAFETY GLYCOSAMINOGLYCAN PEPTIDE COMPLEX IN PATIENTS WITH KNEE OSTEOARTHRITIS AND COMORBIDITY
Presenting author: E. Taskina
Authors: N. Kashevarova, E. Sharapova, S. Anikin, E. Strebkova, K. Telyshev, L. Alekseeva, A. Lila, T. Raskina, E. Otteva, E. Zonova, N. Chichasova, V. Lila, I. Vinogradova, O. Ivanova, S. Yakupova, E. Shmidt
15.20
Channel 1
Oral communication selected from abstracts
‣ OC32 - IDENTIFICATION OF PATIENTS AT LOW, HIGH AND VERY HIGH RISK OF OSTEOPOROTIC FRACTURES IN THE UK USING FRAX
Presenting author: E. V. McCloskey
Authors: N. C. Harvey, H. Johansson, M. Lorentzon, E. Liu, L. Vandenput, J. A. Kanis
15.30
Channel 1
Oral communication selected from abstracts
‣ OC33 - CIRCULATING MICRORNA AS BIOMARKERS OF OSTEOPOROSIS AND FRACTURE RISK
Presenting author: S. Donati
Authors: S. Ciuffi, F. Marini, A. Botta, G. Isaia, P. D'Amelio, C. Marcocci, S. Migliaccio, S. Minisola, J. Pepe, R. Nuti, U. Tarantino, M. L. Brandi
15.40
Channel 1
Oral communication selected from abstracts
‣ OC34 - PALOVAROTENE FOR THE TREATMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA IN FEMALES AGED ≥8 YEARS AND MALES AGED ≥10 YEARS: DATA FROM THE PHASE III MOVE TRIAL
Presenting author: G. Baujat
Authors: R. J. Pignolo, M. Al Mukaddam, M. A. Brown, A. M. Cheung, C. L. De Cunto, P. Delai, E. C. Hsiao, P. Kannu, R. Keen, E. E. Mancilla, S. K. Berglund, R. Marino, A. Strahs, F. S. Kaplan
15.50
Channel 1
Plenary Lecture 10
New approaches of rare skeletal diseases management Maria Luisa Brandi
17.20
Channel 1
Oral communication selected from abstracts
‣ OC35 - MIGHT NSAID USE INTERACT WITH BISPHOSPHONATE EFFICACY? EXPLORATORY ANALYSIS FROM THE CLODRONATE HIP STUDY
Presenting author: E. V. McCloskey
Authors: Z. Zheng, H. Johansson, N. C. Harvey, M. Lorentzon, J. A. Kanis
17.00
Adjournement